How does the coronavirus test work? 5 questions answered | Friday Morning Coffee

By: - March 13, 2020 7:18 am

Gov. Tom Wolf briefs the media at Pennsylvania Emergency Management Agency HQ in suburban Harrisburg on Friday, 3/6/20 (Screen Capture)

Good Friday Morning, Fellow Seekers.

If you feel like this short, already ridiculously long new year can now be safely divided into the time before the coronavirus outbreak and the time after, you’re not alone. State lawmakers will return to Harrisburg next week and a very different Capitol building.

As of Thursday afternoon, there were 22 documented cases of COVID-19 in Pennsylvania and Gov. Tom Wolf had ordered the shutdown of schools and other public venues in the part of suburban Philadelphia hardest hit by the coronavirus, the Capital-Star’s Elizabeth Hardison reported.

As the Capital-Star’s Stephen Caruso also reported Thursday, the big public rallies that are a rite of spring are on hold, and public access to the People’s House is going to be restricted to employees and people with badge and keycard credentials. 

Lawmakers appear likely to turn their attention to long-delayed legislation that would give Gov. Tom Wolf the right to declare a public health emergency.

With that in mind, we’re turning things over to Rochester Institute of Technology biology professor Maureen Ferran, who takes on some key questions about testing for the virus (which are still widely available, as of this writing). She wrote the piece below for The Conversationwhere it first appeared.

Taking a sample is quick, easy and can be done anywhere. Finding out if a person is infected is more complicated. (Rodolfo Parulan Jr./Moment via Getty Images)

1. Who gets tested?

Currently there are two main reasons someone would be tested for the coronavirus: having symptoms or exposure to an infected person.

The main symptoms of COVID-19, the disease caused by the coronavirus SARS-CoV-2, are fever, dry cough and shortness of breath. These look a lot like the flu and the common cold, so it takes a physician to determine if testing for the virus is necessary.

Initially, the Centers for Disease Control and Prevention recommended testing only people with symptoms and who had potentially been exposed to the virus. But to the surprise of public health officials, several of the first people in the U.S. who tested positive for the virus had no obvious exposure. This development suggested that the virus was being transmitted locally, meaning it was spreading from person to person easily and/or that people may have been transmitting the virus without experiencing serious symptoms.

In response, on March 4 the CDC changed its recommendations to allow anyone with COVID-19-like symptoms to be tested as long as a doctor approved the request. Since the number of available tests is limited, the CDC is encouraging physicians to minimize unnecessary testing and consider a patient’s exposure risks before ordering tests.

As of writing this, there are no specific treatments available for COVID-19, but that does not mean testing is pointless. Perhaps most importantly, testing is done so that infected patients can be quarantined and the spread of the virus slowed. Another benefit of testing is that it lets public health workers build a more accurate picture of the number of cases and how the virus is spreading in the population.

Pennsylvania Secretary of Health Dr. Rachel Levine. Source: Pennsylvania Department of Health.

2. What it is like to get tested?

For a patient, the process of being tested for the virus is easy and can potentially be done almost anywhere. It typically involves taking a swab from deep in a patient’s nasal cavity to collect cells from the back of the nose. The sample is then sent to a lab, where it will be tested to determine if the patient’s cells are infected with the virus. The same process is used to collect a sample from a patient who is tested for flu.

3. How does the test work?

While collecting a sample is easy, actually determining whether a person is infected with the coronavirus is much more complicated. The current method looks for the virus’s genetic material (RNA) in a patient’s cells.

In order to detect the presence of RNA in the patient’s sample, labs perform a test called reverse-transcription polymerase chain reaction. This method first converts any viral RNA to DNA. Then the DNA is replicated millions of times until there are enough copies to detect using a specialized piece of equipment called a quantitative PCR instrument.

If genetic material from the virus is found in the sample, then the patient is infected with the virus.

It takes 24-72 hours to get the results of a test. During the early ramp-up of testing, there were some concerns about the test’s accuracy after one study found 3% of tests in China came back negative when the samples were actually positive. But this type of genetic test is generally very accurate – more so even than rapid flu tests – and the benefits of testing outweigh the risk of an error.

4. Does the US have enough tests?

The availability of tests has been a big issue. Prior to Feb. 29, the CDC was the only place approved by the FDA to develop, produce and process tests. However, as the number of suspected cases climbed and doctors approved more people for testing, demand to be tested soared.

The test for the coronavirus requires a kit, specialized equipment and specially trained personnel. Faulty and slow development of test kits and the initial requirement that all tests be processed at the CDC contributed to the slow rollout across the U.S.

As pressure on the federal government to make tests available increased, the FDA announced a new policy on Feb. 29 that made it easier for commercial and academic laboratories to develop their own tests and allowed other certified labs to test patient samples.

Integrated DNA Technologies, a CDC contractor, shipped 700,000 tests to commercial, academic and health care laboratories on March 6. Quest Diagnostics and LabCorp, two large commercial test manufacturers, started making their own test kits, which became available on March 9. Many companies, hospitals and other institutions are now racing to develop more tests to diagnose COVID-19.

On March 10, Alex Azar, secretary of Health and Human Services, announced that 2.1 million testing kits are now available and more than 1 million have shipped to certified labs for testing. Millions more are expected to ship out this week.

WASHINGTON, DC – FEBRUARY 26: U.S. President Donald Trump speaks at the beginning of a new conference with members of the coronavirus task force, including Vice President Mike Pence in the Brady Press Briefing Room at the White House February 26, 2020 in Washington, DC. Trump updated the American people about what his administration’s ‘whole of government’ response to the global coronavirus outbreak. (Photo by Tasos Katopodis/Getty Images)

5. Does everyone really need to be tested?

Realistically, it isn’t feasible to test everyone who is sick in the U.S. Therefore, most health officials believe it is important to prioritize the testing of people who need it the most: those at high risk such as health care workers who have been in contact with COVID-19 patients; symptomatic people in areas with high infection rates; and people 65 years of age and older with chronic health issues, such as heart disease, lung disease or diabetes. As more tests become available, it will be possible to test more people.

There’s also a need to develop faster tests that do not require special equipment and personnel. Testing allows experts to better understand how the outbreak is progressing and try to predict the impact the virus will have on society.

As with all outbreaks, this pandemic will end. In the meantime, however, people need to wash their hands and try to minimize their risk of exposure. There is much to be learned about this novel coronavirus. Only time will tell if it disappears from the human population, as SARS did in 2004, or becomes a seasonal disease like flu.

The Pennsylvania Capitol building. (Capital-Star photo by Sarah Anne Hughes)

Our Stuff.
Elizabeth Hardison
 has what you need to know about the state’s efforts to deal with 22 confirmed coronavirus cases and the Wolf administration’s efforts to contain the outbreak in southeastern Pennsylvania.

The Legislature will conduct its business next week largely behind closed doors. Stephen Caruso talks to open records and government transparency advocates about the implications.

U.S. Sen. Bob Casey nabbed a perfect score on an environmental advocacy group’s legislative scorecard. U.S. Sen. Pat ToomeyErrr … not so much. You can also check out the scores for all 18 members of the state’s U.S. House delegation.

From our partners at the Philadelphia TribuneMayor Jim Kenney wants $85M to fight the coronavirus outbreak in the city.

On our Commentary Page, freshman state Sen. Dave Arnold, R-Lebanon, argues the case for his first bill, one upping the penalties for child pornography offenses. And Lackawanna County’s human services director has a solution to the high turnover among child welfare workers.

(Josh Locatis/Flickr)


‘Ghost guns’ are multiplying in Philadelphia among a wave of violence, the Inquirer reports.
Pennsylvania’s state lab could run out of COVID-19 tests if the CDC doesn’t provide it with more, the Post-Gazette reports.
Pennsylvanians are seeing price gouging on soap and hand sanitizerAttorney General Josh Shapiro’s office says (via PennLive).
Schools around the Lehigh Valley, like others across the state, are closing in response to the outbreak, the Morning Call reports.

Here’s your #Pennsylvania Instagram of the Day:

One in three sanctuary families in Pennsylvania are walking free with approval from the federal governmentWHYY-FM reports.
The head of the Pa. State System of Higher Education says rising costs are driving an enrollment decline, the PA Post reports.
With virus-rated cancellations growing, state officials are weighing how far to reports.
A GOP PAC is targeting U.S. Rep. Matt Cartwright, D-8th District, over a trucking bill, PoliticsPA reports.

What Goes On.
Gov. Tom Wolf 
and Secretary of Health Dr. Rachel Levine offer the latest info on the COVID-19 coronavirus impact during a briefing at PEMA HQ. Scheduled time is noon. Plan for that to be moved.

Heavy Rotation.
Here’s one from Maggie Rogers that recently caught our ear. It’s ‘Light On.’

The Last Gratuitous Hockey Link for a While.
The NHL announced Thursday that it was postponing the rest of the 2019-20 season because of the coronavirus outbreak.

And now you’re up to date.

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